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P3‐406: DISTINCT LONGITUDINAL CORTICAL ATROPHY IN NON‐AMNESTIC COMPARED TO AMNESTIC ALZHEIMER'S DISEASE SUGGESTS DIFFERENT PATTERNS OF SPREADING PATHOLOGY
Author(s) -
Da Re Fulvio,
Phillips Jeffrey S.,
Xie Sharon X.,
Ferrarese Carlo,
McMillan Corey T.,
Irwin David J.,
Grossman Murray
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1769
Subject(s) - atrophy , posterior cortical atrophy , pathology , alzheimer's disease , medicine , entorhinal cortex , neocortex , episodic memory , neuroscience , voxel based morphometry , magnetic resonance imaging , hippocampus , psychology , disease , white matter , dementia , cognition , radiology
Figure 1. (A) The progression of neurofibrillary tangle (NFT) pathology in the medial temporal lobe in Braak stages I and II. Braak stages III-VI are not shown. NFT pathology starts in trans-entorhinal area (lateral ERC/BA35) and precedes to the ERC and the hippocampus. (B) The two dominant anatomical variants of the medial temporal lobe, defined by the folding patterns of the collateral sulcus (CS). Variant 1 has deep and continuous CS while variant 2 has discontinuous CS. Figure adapted from (Xie et al., 2017; Braak and Braak, 1995; Ding and Van Hosesen, 2010). Fulvio Da Re, Jeffrey S. Phillips, Sharon X. Xie, Carlo Ferrarese, Corey T.McMillan, David J. Irwin, MurrayGrossman, University of Milano-Bicocca, Milan, Italy; School of Medicine and Surgery, Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy; Penn Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Contact e-mail: dare.fulvio@gmail. com