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P3‐400: A NOVEL METHOD FOR DEFINING INDIVIDUAL METABOLIC NETWORKS DERIVED FROM [18F]FDG PET DATA
Author(s) -
Rodrigues Yuri Elias,
Schu Peixoto Guilherme G.,
Silva da Rocha Andreia,
Gehres Sarah Wehle,
Fontana Igor C.,
Manica Evandro,
Souza Diogo O.,
Carter Stephen F.,
Zimmer Eduardo R.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1762
Subject(s) - positron emission tomography , context (archaeology) , medicine , nuclear medicine , mathematics , biology , paleontology
associations with memory performance in mutation carriers and non-carriers from the Colombian Presenilin-1 (PSEN1) E280A kindred. Methods:We used structural MRI, PiB-PET, Flortaucipir (FTP)-PET, and memory testing (CERAD Word List Recall) for the assessment of 12 unimpaired mutation carriers (mean age1⁄4 3763), approximately 7 years before the kindred’s median age at mild cognitive impairment (MCI) onset, and 24 agematched non-carrier family members. Automated brain mapping algorithms were used to compute mean cortical PiB DVRs, entorhinal cortex (EC) and inferior temporal (IT) flortaucipir SUVRs. Cortical thickness was measured in the signature of familial AD (Weston et al., 2016), which included 6 regions: entorhinal cortex, inferior parietal cortex, precuneus, superior parietal cortex, superior frontal cortex, and supra marginal gyrus. Spearman’s correlations were used to characterize relationships among these brain imaging and memory measurements. Results:Compared to non-carriers, unimpaired PSEN1 mutation carriers showed cortical thinning in the FAD signature (p1⁄40.001). In the carrier group, cortical thinning in the mean signature summary measure was not associated with amyloid burden, but was associated with EC tau levels (r1⁄4-0.75; p-value1⁄4 0.02). EC and IT tau were associated with thinning in precuneus, superior frontal cortex, and superior parietal cortex (p<0.05). Further, worse memory performance was associated with a lower mean cortical thickness in the familial AD signature (r1⁄4 0.73; p-value: 0.005). Conclusions:This study provides preliminary information about the limited associations between amyloid burden and cortical thinning in preclinical autosomal dominant AD. Findings suggest that regional tau burden is associated with cortical thinning and memory decline in individuals at virtually certain risk for Alzheimer’s disease, more than 5 years prior to symptom onset.