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P3‐379: BRAIN DIFFUSION TENSOR IMAGING METRICS IN ISCHEMIC LESIONS IN VASCULAR COGNITIVE IMPAIRMENT
Author(s) -
Haddad Seyyed M.H.,
Scott Christopher J.M.,
Ozzoude Miracle,
Arnott Stephen R.,
Black Sandra E.,
Dowlatshahi Dar,
Strother Stephen C.,
Swartz Richard H.,
Symons Sean,
Montero-Odasso Manuel,
Bartha Robert
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1741
Subject(s) - diffusion mri , fractional anisotropy , dementia , neuroimaging , vascular dementia , medicine , hyperintensity , white matter , stroke (engine) , artifact (error) , pathology , magnetic resonance imaging , radiology , disease , psychology , neuroscience , psychiatry , mechanical engineering , engineering
related to SUVR (p < .001). Mean SUVR was 1.56 6 1.32 for APOEε4 genotype carriers (E4+) and 1.30 60.23 for non-carriers (E4-) (p< .001). There was no significant main effect for age, gender or ethnicity on SUVR. However, the following interactions were present: (1) SUVR for E4+White non-Hispanics (WNHs) was higher than E4+ Hispanics, but E4WNHs had lower SUVR than E4Hispanics; (2) E4+ males had higher SUVR than E4+ females. The optimal SUVR threshold for amyloid positivity among all subjects (n1⁄4152), using ROC analyses and Youden’s criteria, was 1.42 (sensitivity 1⁄494%; specificity 1⁄4 92.5 %). For E4subjects this threshold was 1.33 and 1.45 for E4+ subjects. Conclusions:Amyloid load was not significantly influenced by age, gender, ethnicity and cognitive status, other than the interactions between E4 status, ethnicity and gender, but was higher among E4+ than E4subjects, as was the optimal SUVR threshold for amyloid positivity. Research studies in which quantitative thresholds for amyloid positivity are used should consider the impact of E4+ and E4status, and the resulting clinical progression rates.