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P3‐377: COMPARING HIPPOCAMPAL EFFECT SIZE BETWEEN ALZHEIMER'S DISEASE AND HEALTHY CONTROLS USING OLDER AND NEWER VERSIONS OF SPM AND FREESURFER
Author(s) -
Deardorff Rachael,
Groot Colin,
Zalewski Kody,
Ossenkoppele Rik,
Donald Christine Mac,
West John D.,
Mormino Beth C.,
Saykin Andrew J.,
Crane Paul K.,
Risacher Shan L.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1739
Subject(s) - neuroimaging , hippocampal formation , voxel , voxel based morphometry , alzheimer's disease neuroimaging initiative , medicine , psychology , reproducibility , neuroscience , audiology , nuclear medicine , magnetic resonance imaging , cognitive impairment , white matter , cognition , radiology , mathematics , statistics
Background: Cerebral microinfarcts (CMI) have been commonly observed in Alzheimer’s Disease (AD) and associated with cognitive impairment (vanVeluw et al., 2017). Previous animal studies demonstrated that CMI may impair white matter pathways and affect brain function that extends beyond lesion boundaries (Summers et al., 2017). Nevertheless, how CMI influences brain structural connectivity in living humans remains largely unknown. Hence, we for the first time aimed to investigate topological features of brain structural networks in relation to CMI presence. We hypothesized that patients with CMI would show disrupted structural network topology in higher-order cognitive networks (the default mode (DMN) and executive networks (ECN)) (Chong et al., 2017). Methods:We examined the structural connectivity based on diffusionMRI data of 92 AD (26 with CMI), 83 cognitive-impairment-no-dementia (CIND, 28 with CMI) and 28 healthy controls without CMI (Table 1). CMIs were