Premium
P3‐375: CHARACTERISTIC BRAIN VOLUMETRIC CHANGES IN THE AD PRECLINICAL SIGNATURE
Author(s) -
Petrone Paula Marcela,
Casamitjana Adriá,
Falcon Carles,
Artigues Miquel,
Operto Grégory,
Skouras Stavros,
Cacciaglia Raffaele,
Molinuevo José Luis,
Vilaplana Verónica,
Gispert Juan Domingo,
Salvadó Gemma
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1737
Subject(s) - precuneus , magnetic resonance imaging , atrophy , medicine , asymptomatic , cerebrospinal fluid , dementia , pathology , neuroimaging , neuroscience , psychology , functional magnetic resonance imaging , radiology , disease
biomarker severity from CON to AD, with SCD showing a small, but significant difference from CON in the EC and HPC. Results: Qualitatively, morphometry results showed a gradient of changes from CON to AD in the EC and HPC (Figure 1), especially for the left EC and right HPC, but with SCD not significantly different from CON. Furthermore, compared to CON, SCD had significant lower right lingual surface (p1⁄4.021), left posterior cingulate thickness (p1⁄4.026), right rostral anterior cingulate thickness (p1⁄4.012), left supramarginal surface (p1⁄4.019) and volume (p1⁄4.039), however none of those differences resisted FDR correction. Grading results (Figure 2) were similar to morphometry, with a gradient of changes from CON to AD, especially for the left EC and right HPC, but no significant difference between SCD and CON. Conclusions:Based on these results, baseline morphometric measures and TPMDgrading scores for EC and HPC do not capture the difference related to the cognitive complaint between SCD and CON. Longitudinal follow-up is required to determine their positive predictive values for AD pathology.