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P3‐367: PET AMYLOID IMAGING WITH FLORBETAPIR AND COGNITION IN THE OLDEST‐OLD: THE 90+ STUDY
Author(s) -
Corrada Maria M.,
Sajjadi S. Ahmad,
Greenia Dana,
Fletcher Evan,
DeCarli Charlie S.,
Kawas Claudia H.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1729
Subject(s) - precuneus , cognition , dementia , cognitive decline , medicine , posterior cingulate , verbal fluency test , cognitive test , effects of sleep deprivation on cognitive performance , psychology , gerontology , clinical psychology , audiology , psychiatry , disease , neuropsychology
however, largely varies across monocenter studies, and results from multicenter studies are still scarce. In the present study, we assessed the robustness and diagnostic utility of functional connectivity (FC) and the amplitude of low-frequency fluctuations (ALFF) derived from multicenter rs-fMRI in a large prospective multicenter cohort using identical scanning p rotocols and high-level standardized procedures. Methods: Baseline data of N1⁄4247 participants from the DZNE Longitudinal Cognitive Impairment and Dementia (DELCODE) study were included in the analysis. FC and fALFF were calculated from the low-frequency signal fluctuations of the rsfMRI time series and averaged using a functionally defined atlas. Elastic-net penalized logistic regression models were applied to differentiate between individuals with subjective cognitive decline (SCD), amnestic mild cognitive impairment (MCI), or AD dementia and cognitively normal controls. Results were evaluated using repeated tenfold cross-validation. Results: Quality control results showed a more homogeneous temporal signal-to-noise ratio (tSNR) across centers than in a previous multicenter rs-fMRI study using heterogeneous scanning protocols (Fig.1). Resting state FC reached significant group discrimination only for the comparison of AD dementia cases with healthy controls, but not for the other diagnostic groups (Fig.2). AD dementia cases showed alterations in a large range of intrinsic resting state networks, including the default mode and salience networks, but also executive and language networks. When groups were stratified according to their CSF amyloid status that was available in a subset of cases, diag-