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P3‐354: PHYSICIAN‐PERCEIVED RISKS AND BENEFITS OF AMYLOID IMAGING IN A PRECLINICAL POPULATION
Author(s) -
Karunungan Krystal,
Karlawish Jason,
Gonzalez Rosa,
Arias Jalayne J.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1716
Subject(s) - medicine , dementia , biomarker , disease , amyloid (mycology) , population , asymptomatic , oncology , clinical psychology , pathology , environmental health , biochemistry , chemistry
cingulate to left supramarginal gyrus (r1⁄4 0.956, p< 2.0 x 10; Fig. 2). This relationship was not impacted by age or grey matter volume. No regions related to attention or executive function reached significance. Conclusions: Prior to dementia onset, we find that increased rs-fMRI strength within the DMN is positively related to memory scores. Compared to controls, previous work has found widespread increases in brain synchrony in those with DS (Anderson et al. 2013), and our own work has found both increased and decreased synchrony within the DMN (Koenig et al. 2015; 2017). Future work will include additional participants and will compare rs-fMRI to biological measures related to dementia. This work was supported by Alzheimer’s Association. The authors acknowledge technical support by Siemens Medical Solutions.