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P3‐307: THE ASSOCIATION BETWEEN APATHY AND STRUCTURAL BRAIN ALTERATIONS IN AMNESTIC MILD COGNITIVE IMPAIRMENT
Author(s) -
Setiadi Tania M.,
Opmeer Esther M.,
Tumati Shankar,
Reesink Fransje E.,
De Deyn Peter Paul,
Aleman André
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1668
Subject(s) - apathy , psychology , voxel based morphometry , grey matter , association (psychology) , posterior cingulate , white matter , audiology , medicine , cognition , neuroscience , magnetic resonance imaging , radiology , psychotherapist
target memory functions. Methods: Nineteen older adults with aMCI (13F; Age: Mean 1⁄4 71.58 years, SD 1⁄4 7.12; Mini-Mental State Examination score: Mean 1⁄4 27.89, SD 1⁄4 1.70; Clinical Dementia Rating score: Mean 1⁄4 0.5) served as participants. They completed two tests that evaluated the use of inherent memory strategies: strategy subscale of the Multifactorial Memory Questionnaire (MMQ; Troyer & Rich, 2002) and a strategic attention task. In addition, all participants completed standardized cognitive assessments including the logical memory subtest of the Wechsler Memory Scale-III (WMS-III; Wechsler, 1997). The strategy subscale of MMQ required participants to score how often they used various memory strategies. The strategic attention task examined participant’s word recall using three different word lists. In each list, words were worth either a high or a low point value, requiring participants to use inherent memory strategies to encode and recall high value words to maximize their score. Correlations were examined between measures of logical memory subtest (immediate and delayed scores) and MMQ strategy subscale (total score), and measures of logical memory subtest (immediate and delayed scores) and strategic attention task (number of high and low value words recalled). Results: Significant positive correlations were found between logical memory delayed score and both total score of the MMQ strategy subscale, r(17) 1⁄4 0.581, p 1⁄4 .009, and number of high value words recalled in list three of the strategic attention task, r(17) 1⁄4 0.515, p 1⁄4 0.024. Conclusions:The findings demonstrate that better use of inherent memory strategies is associated with better memory performance in individuals with aMCI. These findings lend support for the use of strategy-based memory interventions in this population.