P3‐297: WHAT WILL I BE LIKE NEXT YEAR? IMPACT OF FRONTOTEMPORAL DISORDER PHENOTYPE ON LOSS OF FUNCTIONAL INDEPENDENCE

structural connectivity between groups, a network-based statistics (NBS) analysis using Diffusion tensor imagin (DTI) was performed. Results:A total of 217 subjects were included for analysis (normal control; N1⁄453, AbaMCI; N1⁄466, Ab+ aMCI; N1⁄456, disease control; N1⁄442). In spite of similar clinical manifestations and disease severity, qualitative comparison between the aMCI groups stratified by the brain Ab status demonstrated that Ab+ aMCI was more similar to AD than AbaMCI in terms of semantic memory disruption. Reduced structural connectivity in the bilateral medial frontal areas were implicated in Ab+ aMCI when compared to CN, suggesting the vulnerability of the regional neural network to Ab pathology. Conclusions: The semantic memory network may be susceptible in the stage of prodromal AD. In this regard, semantic memory may serve as a potential early indicator of brain Ab pathology along with episodic memory.