Premium
P3‐297: WHAT WILL I BE LIKE NEXT YEAR? IMPACT OF FRONTOTEMPORAL DISORDER PHENOTYPE ON LOSS OF FUNCTIONAL INDEPENDENCE
Author(s) -
Sweeney Kristin K.,
Quimby Megan,
Wong Bonnie,
Brandt Katie,
Eldaief Mark C.,
McGinnis Scott,
Dickerson Brad C.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1657
Subject(s) - confounding , frontotemporal dementia , medicine , disease , clinical phenotype , primary progressive aphasia , psychology , clinical psychology , phenotype , dementia , gene , biochemistry , chemistry
structural connectivity between groups, a network-based statistics (NBS) analysis using Diffusion tensor imagin (DTI) was performed. Results:A total of 217 subjects were included for analysis (normal control; N1⁄453, AbaMCI; N1⁄466, Ab+ aMCI; N1⁄456, disease control; N1⁄442). In spite of similar clinical manifestations and disease severity, qualitative comparison between the aMCI groups stratified by the brain Ab status demonstrated that Ab+ aMCI was more similar to AD than AbaMCI in terms of semantic memory disruption. Reduced structural connectivity in the bilateral medial frontal areas were implicated in Ab+ aMCI when compared to CN, suggesting the vulnerability of the regional neural network to Ab pathology. Conclusions: The semantic memory network may be susceptible in the stage of prodromal AD. In this regard, semantic memory may serve as a potential early indicator of brain Ab pathology along with episodic memory.