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P3‐289: HARMONIZATION OF SCD OPERATIONALIZATION ACROSS DIFFERENT MEMORY CLINIC SETTINGS: THE EURO‐SCD STUDY
Author(s) -
Jessen Frank,
Wolfsgruber Steffen,
Daamen Marcel,
Molinuevo José Luis,
Teunissen Charlotte E.,
Rami Lorena,
Coll-Padros Nina,
Bouwman Femke H.,
Slot Rosalinde E.R.,
Sikkes Sietske A.M.,
Wesselman Linda M.P.,
Peters Oliver,
Buerger Katharina,
Priller Josef,
Laske Christoph,
Teipel Stefan J.,
Spottke Annika,
Heneka Michael T.,
Düzel Emrah,
Drzezga Alexander,
Boecker Henning,
Flier Wiesje M.,
Wagner Michael
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1649
Subject(s) - medicine , memory clinic , cohort , dementia , biomarker , operationalization , prospective cohort study , disease , oncology , pathology , biology , biochemistry , philosophy , epistemology
sequential sensory stimuli are separated in time and is defined as the minimum interval at which paired sequential stimuli are perceived as being asynchronous and relies on the integrity of basal ganglia, which functions as an internal clock modulated by dopaminergic transmission, and S1 (Lee et al.2018). Aim of the present study was to investigate whether temporal processing evaluated by STDT is altered in MCI and AD compared to healthy subjects. Methods: We enrolled 44 patients (16 MCI, 28 mild-moderate AD) and 50 age-matched healthy volunteers. Patients underwent a complete neuropsychological evaluation. Paired tactile stimuli for STDT testing consisted of square-wave electrical pulses delivered with a constant current stimulator (Digitimer DS7AH) through surface electrodes over the distal phalanx of the index finger. The intensity used for STDT testing was the minimal intensity the subject perceived in 10 out of 10 consecutive stimuli. The first of three consecutive ISIs at which participants recognized the stimuli as temporally separate was considered the STDT and was defined as the average of three STDT trials and entered in the data analysis. Results: STDT values were significantly different across groups of AD, MCI and healthy subjects (Kruskall-Wallis H test1⁄4 85,8, p<0.001). Post-hoc analysis showed that STDT values in patients with MCI (p<0.001) and AD (p<0.001) were higher than those in healthy controls whereas STDT did not significantly differ between MCI and AD. Conclusions:The increase of STDT values in AD and MCI may reveal an alteration of the temporal processing based on the internal clock, depending on dopaminergic transmission, since the early phase. As no differences were found between AD and MCI, STDT could represent a neurophysiological marker of disease status and should also be investigated in patients with subjective memory complaints.