Premium
P3‐274: COMBINATION OF A FUNCTIONAL SYNAPTIC BIOMARKER (ERP) AND VERBAL FLUENCY TEST TO SELECT AMYLOID POSITIVE ELDERLY SUBJECTS IN CLINICAL TRIALS
Author(s) -
Bennys Karim,
Berr Claudine,
Delrieu Julien,
Andrieu Sandrine,
Vellas Bruno,
Touchon Jacques,
Gabelle Audrey
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1634
Subject(s) - p3b , verbal fluency test , psychology , logistic regression , neuropsychology , biomarker , medicine , neuropsychological test , audiology , oncology , event related potential , cognition , neuroscience , biology , biochemistry
amplitude all showed a decrease in the placebo group, whereas they increased in the PQ912 group, indicating an improved global functional connectivity in the latter. The AEC showed a significant effect (mean change: placebo1⁄4-0.0054 versus PQ9121⁄40.0044, t-test: p1⁄40.025, Cohen’s d1⁄40.45) and the TCR-amp showed a trend (mean change: placebo1⁄4-0.0012 versus PQ9121⁄40.0018, p1⁄40.065, d1⁄40.37). The effect measured by AEC remained significant when corrected for sex, country, ApoE, age and baseline value, and additionally for EEG measures of oscillatory activity (global relative power measures in 5 frequency bands; both ANCOVA models p<0.05). There was no correlation between global relative theta power and AEC (r1⁄40.12, p1⁄40.22). Conclusions: Functional connectivity, measured with AEC, significantly improved with PQ912 treatment compared to placebo. This effect sustained when corrected for demographic variables, baseline value and EEG relative power measures.