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P3‐266: CORTICAL NETWORK TOPOLOGY IN PRODROMAL AND MILD DEMENTIA DUE TO ALZHEIMER'S DISEASE: GRAPH THEORY APPLIED TO RESTING STATE EEG
Author(s) -
Bonanni Laura,
Franciotti Raffaella,
Falasca Nicola Walter,
Arnaldi Dario,
Famà Francesco,
Babiloni Claudio,
Onofrj Marco,
Nobili Flavio Mariano
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1626
Subject(s) - assortativity , clustering coefficient , degree (music) , dementia , prodromal stage , resting state fmri , graph theory , average path length , mathematics , graph , topology (electrical circuits) , cluster analysis , complex network , computer science , disease , psychology , medicine , neuroscience , statistics , shortest path problem , combinatorics , physics , acoustics
interactive effect of DM and AD risk factors on rate of functional decline in older adults without a neurocognitive disorder. Methods: Participants without MCI or dementia from the Alzheimer’s Disease Neuroimaging Initiative underwent annual assessments that included the Functional Activities Questionnaire (FAQ), an informant-rated measure of everyday functioning in which higher scores indicate more functional difficulty. Multilevel modeling, controlling for demographics and ischemic risk, examined the interactive effects of baseline DM (DM positive status [+] n1⁄468; DM negative status [-] n1⁄4739) and AD risk factors in the prediction of four-year longitudinal change in everyday functioning. One MLM was run for each AD risk factor, including: subtle cognitive decline (SCD+ n1⁄4256; SCDn1⁄4492), genetic susceptibility (APOE ε4+ n1⁄4269; APOE ε4n1⁄4535), cerebrospinal fluid Ab (Ab+ n1⁄4263; Abn1⁄4323), t-tau (t-tau+ n1⁄4120; t-taun1⁄4461), and p-tau (ptau+ n1⁄4366; p-taun1⁄4220). Results:Compared to DM-, DM+ participants were more likely to be male and had higher ischemic risk. The three-way DM x AD risk factor x Visit interaction was significant for models that examined SCD (p1⁄4.031; Fig. 1), APOE ε4 (p1⁄4.001; Fig. 2), t-tau (p1⁄4.022; Fig. 3), and p-tau (p1⁄4.041; Fig. 4), but not Ab (Fig. 5). DM moderated the relationship between AD risk factors (except Ab) and longitudinal functional trajectories such that having DM increased the rate of functional decline for those who were positive for each of these risk factors. Conclusions: Participants who were positive for both DM and an AD risk factor demonstrated the fastest rate of functional decline, and only these participants reached an impaired level of functional difficulty within four years (FAQ score >5). DM+ status did not modify the relationship between Ab and functional decline. Future work should identify potential mechanisms for the modifying effect of DM on SCD, APOE ε4, and CSF biomarkers (t-tau and p-tau) across the aging spectrum.