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P3‐219: COMPARING SLEEP AND ACTIVITY OUTCOMES IN INDIVIDUALS WITH ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT USING ACTIGRAPHY
Author(s) -
Thomas Neil W.,
Mattek Nora,
Riley Thomas,
Witter Phelps,
Reynolds Christina L.,
Austin Johanna,
Sharma Nicole,
Marcoe Jennifer,
Kaye Jeffrey A.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1578
Subject(s) - actigraphy , sleep (system call) , polysomnography , medicine , physical therapy , cognitive impairment , activities of daily living , cognition , activity monitor , physical medicine and rehabilitation , psychology , gerontology , circadian rhythm , physical activity , psychiatry , electroencephalography , operating system , computer science
accuracies in distinguishing between different diagnostic groups were as follows: 1) the combination [Ab1-42+p-tau+NFL] differentiated ADD patients from HC with an AUROC of 0.86 (95% confidence interval [CI], 0.83-0.89); 2) total tau and [Ab1-42+ptau+YKL-40] combination discriminated ADD from FTD patients with an AUROC of 0.82 (95% CI, 0.78-0.86) and 0.81 (95% CI, 0.77-0.85), respectively; 3) total tau and [p-tau+YKL-40] combination distinguished FTD patients from HC with an AUROC of 0.78 (95% CI, 0.73-0.83) and 0.73 (95% CI, 0.67-0.79), respectively. Conclusions:Our data indicate that none of the multivariate combinations performed superior to the gold-standard core, feasible biomarkers in the classification of HC from MCI, HC from ADD, HC from FTD, MCI from ADD, and ADD from FTD patients. Future independent validation of our findings in larger multicenter cohorts is warranted to confirm and expand on our data. Particularly, longitudinal analyses are needed in asymptomatic preclinical at risk for AD individuals to investigatewhether components of the biomarker panel valuably predict disease progression and conversion to clinical milestones, including prodromal stage and dementia.