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P3‐213: MORE POWERFUL STATISTICAL APPROACHES FOR LONGITUDINAL COMPARISONS OF AD SUBTYPES ON CSF AND IMAGING BIOMARKERS FROM DOMINANTLY INHERITED ALZHEIMER NETWORK (DIAN) AND ALZHEIMER'S DISEASE NEUROIMAGING INITIATIVE (ADNI)
Author(s) -
Xiong Chengjie,
Buckles Virginia D.,
McCue Lena,
Coble Dean W.,
Beckett Laurel,
Weiner Michael,
Shaw Leslie M.,
McDade Eric,
Fagan Anne M.,
Benzinger Tammie L.S.,
Hassenstab Jason,
Bateman Randall J.,
Morris John C.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1572
Subject(s) - milestone , alzheimer's disease neuroimaging initiative , generalized linear mixed model , neuroimaging , mixed model , longitudinal data , linear model , missing data , statistics , medicine , oncology , computer science , alzheimer's disease , psychology , mathematics , data mining , disease , neuroscience , geography , cartography
scores) and 0.89 (high GDS scores). When continuously correlating AUC values of respective tests with GDS scores a general increase could be observed – the higher GDS scores, the higher AUC values. Conclusions:Our analyses revealed CPS as robust screening instrument to identify possible underlying AD in subjects with elevated GDS scores suggesting clinically relevant depressive symptoms. Furthermore neuropsychological tests seem to get more significant with increasing number of depressive symptoms. Our findings regarding subjects with low GDS scores are in line with our earlier work, showing word list tasks to be predictive of possible AD. Easy to apply neuropsychological tests are important to identify traces for neurodegenerative processes when depressive symptoms and cognitive deficits appear in parallel.