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P3‐172: CIP2A‐PP2A SIGNALING CAUSES TAU/APP PHOSPHORYLATION, SYNAPTOPATHY AND MEMORY DEFICITS IN ALZHEIMER'S DISEASE
Author(s) -
Shentu Yangping,
Huo Yuda,
Feng Xiaolong,
Gilbert James,
Wang Jianzhi,
Wang Xiaochuan,
Westermarck Jukka,
Man Hengye,
Liu Rong
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1530
Subject(s) - protein phosphatase 2 , tauopathy , hyperphosphorylation , phosphorylation , tau protein , neuroscience , microbiology and biotechnology , biology , alzheimer's disease , phosphatase , disease , medicine , neurodegeneration
investigate correlation between synaptic activity and behavior. Quantal analysis of light-evoked IPSCs differentiate preand postsynaptic mechanisms of action. Baclofen (30mM) was used to illustrate a clear pre-synaptic action while Memantine (3-30mM) had mixed preand postsynaptic actions. Action of these drugs in calcium buffering is also being investigated. Continuing experiments with glutamate modulators are allowing us to uncover a novel mechanism of action for memantine. Conclusions:Our data so far has illustrated the potential of using quantal analysis in an optogenetic model in order to study preand post-synaptic actions of glutamate and calcium modulators in the neuron. Ultimately, we will be able to determine the mechanism of action of memantine in the Basal forebrain during aging.