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P1‐150: STRAIN BACKGROUND MODIFIES TRANSCRIPTOMIC SIGNATURES IN AN EARLY‐ONSET ALZHEIMER'S MOUSE MODEL
Author(s) -
Uyar Asli,
Onos Kristen D.,
Keezer Kelly J.,
Williams Harriet M.,
O'Rourke Rita,
Buchanan Rebecca,
Howell Gareth,
Carter Gregory W.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.153
Subject(s) - biology , congenic , phenotype , genetics , neurodegeneration , inbred strain , strain (injury) , transcriptome , gene , trem2 , microglia , hypoactivity , genotype , genetically modified mouse , neuroinflammation , disease , transgene , gene expression , neuroscience , immunology , cell , pathology , medicine , myeloid cells , anatomy , inflammation
Eric Boerwinkle, Gerard Schellenberg, Tatiana M. Foroud, Li-San Wang and Alzheimer’s Disease Sequencing Project Data Flow Work Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Indiana University School of Medicine, Indianapolis, IN, USA; Baylor College of Medicine, Houston, TX, USA; University of Pennsylvania, Philadelphia, PA, USA; The Broad Institute, Cambridge, MA, USA; The Genome Institute, Washington University, St. Louis, MO, USA; Boston University School of Public Health, Boston, MA, USA; University of Miami, Miami, FL, USA; Columbia University, New York, NY, USA; Boston University School of Medicine, Boston, MA, USA; University of Washington, Seattle, WA, USA; Boston University, Boston, MA, USA; University of Texas Health Sciences Center, San Antonio, TX, USA; University of Texas Health Science Center at Houston, Houston, TX, USA. Contact e-mail: apartch@pennmedicine.upenn.edu