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P3‐171: TARGETING TRANSLATION IMPAIRMENT TO RESTORE COGNITIVE DEFICITS IN ALZHEIMER'S DISEASE MODELS
Author(s) -
Oliveira Mauricio M.,
Lourenco Mychael V.,
Longo Francesco,
De Felice Fernanda Guarino,
Klann Eric,
Ferreira Sergio Teixeira
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1529
Subject(s) - morris water navigation task , fear conditioning , neuroscience , translation (biology) , memory impairment , cognition , hippocampus , pharmacology , psychology , medicine , chemistry , biochemistry , amygdala , messenger rna , gene
investigate correlation between synaptic activity and behavior. Quantal analysis of light-evoked IPSCs differentiate preand postsynaptic mechanisms of action. Baclofen (30mM) was used to illustrate a clear pre-synaptic action while Memantine (3-30mM) had mixed preand postsynaptic actions. Action of these drugs in calcium buffering is also being investigated. Continuing experiments with glutamate modulators are allowing us to uncover a novel mechanism of action for memantine. Conclusions:Our data so far has illustrated the potential of using quantal analysis in an optogenetic model in order to study preand post-synaptic actions of glutamate and calcium modulators in the neuron. Ultimately, we will be able to determine the mechanism of action of memantine in the Basal forebrain during aging.