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P3‐156: THE CYSTEINE‐RICH WHEY PROTEIN, IMMUNOCAL®, RESCUES REELIN EXPRESSION IN THE HAPP SWEIND TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE
Author(s) -
Duval Nathan,
Sandberg Alexandra,
Fleming Holly,
Linseman Daniel
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1514
Subject(s) - reelin , entorhinal cortex , hippocampal formation , dentate gyrus , hippocampus , neuroscience , dab1 , population , morris water navigation task , biology , microbiology and biotechnology , medicine , environmental health , extracellular matrix
TOM1, a FcgRIIb2-binding protein, through repressed receptor recycling. TOM1 expression was down-regulated in the hippocampus of 3x Tg-AD mice and AD patients. Conclusions: Cytosolic accumulation of Ab, including mitochondria, via endocytic compartments caused cytotoxicity. Moreover, neuronal accumulation of Ab in both sexes of 3x Tg-AD mice and memory deficits in male 3x Tg-AD mice were ameliorated by forebrain-specific expression of Ab-uptake-defective Fcgr2b mutant. Our findings suggest that FcgRIIb2 is essential for neuropathic uptake of Ab in AD. Acknowledgments: Y. Gwon, and S.H. Kim were in part supported by the BK21 program and Global Ph.D. program. This work was supported by Samsung Science and Technology Foundation under Project Number SSTFBA0000 and partly by the CRI grant (NRF2013R1A2A1A01016896) funded by the Ministry of Education, Science, and Technology.