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P3‐149: THE ANTIOXIDATIVE EFFECT OF ASTAXANTHIN ON GLIAL ACTIVATION INDUCED BY OLIGOMERIC OR FIBRILLAR Aβ 1‐42 IN VITRO
Author(s) -
Guo Ling,
Qiao Tingting,
Chen Zhongyi,
Dong Baolian,
Li Hui,
Zhao Yanan
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1506
Subject(s) - neuroinflammation , oxidative stress , microglia , chemistry , astaxanthin , in vitro , downregulation and upregulation , lipopolysaccharide , microbiology and biotechnology , biochemistry , inflammation , biology , endocrinology , immunology , carotenoid , gene
3NT and 4HNE in a dose-response manner in N2a-APP/swe cells. Treatment with anti-oxidant agent n-acetyl-cysteine (NAC) rescued the nPM-induced neurotoxicity by reducing oxidative stress, Ab levels and lipid raft alteration. Conclusions:We propose that nPM exposure induced oxidative stress with consequent alteration of protein levels in lipid raft enriched fractions. These alterations might facilitate the interaction of APP with secretase complexes and mediate the pro-amyloidogenic processing of APP, with a dose-dependent hierarchy.