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P3‐143: GINSENOSIDES PROTECT NA/K‐ATPASE ACTIVITY PREVENTING SYNAPTIC DYSFUNCTION IN APP/PS1 MICE
Author(s) -
Gong Yuesong,
Ding Yu,
Wang Shanshan,
Ding Rong
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1500
Subject(s) - ampa receptor , synapse , glutamate receptor , dendritic spine , nmda receptor , chemistry , postsynaptic potential , neuroscience , microbiology and biotechnology , receptor , biology , biochemistry , hippocampal formation
oxidase (MAO), membrane bound ATPases, intracellular calcium levels and lipid peroxidation in presence of neuropeptides. Results: The results obtained in the present work revealed that increased activities of antioxidant enzymes, membrane bound ATPases and decrease in level of calcium levels, MAO actiivty and lipid peroxidation in presence of NKB and combined NKB and Ab in vivo estradiol (E2) treated aging rat brain. NKB treatment reversed the beneficial in preventing some of the age related changes in the brain. An in vitro incubation of E2 treated synaptosomes with Ab showed toxic effects on all the parameters, while NKB showed stimulating effects and the combined NKB and Ab showed a partial effects as compared to Ab (25-35) and NKB alone. Conclusions: Present study elucidates an antioxidant, neuromodulatory and neuroprotective role of tachykinin peptide NKB against the beta amyloid induced toxicity in E2 treated female rats. NKB treatment reversed the beneficial in preventing some of the age related changes in the brain.