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P3‐125: NUCLEOSKELETON DYSREGULATION IS MEDIATED BY LMNA IN ALZHEIMER'S DISEASE
Author(s) -
Wen Natalie,
Li Zeran,
Harari Oscar,
Cruchaga Carlos,
Karch Celeste
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1482
Subject(s) - lmna , progeria , lamin , biology , nuclear lamina , microbiology and biotechnology , progressive supranuclear palsy , neuroscience , pathology , nuclear protein , genetics , medicine , gene , nucleus , atrophy , transcription factor
be upregulated in other transgenic AD models. One interesting downregulated gene codes for the zinc finger protein ZBTB20, which is critical for hippocampal development and function and regulates neurons and astrocytes. Conclusions:These data highlight novel pathways involved in the development of AD-associated neuropathology and provide new insights about mechanisms relevant for progression of disease. Ultimately, genomic findings identified in these mouse models will be compared with data from extensive datasets generated by our group from ongoing studies of human AD.