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P3‐108: IDENTIFICATION OF MITOCHONDRIAL VARIANTS ASSOCIATED WITH LATE‐ONSET ALZHEIMER'S DISEASE
Author(s) -
Zhang Xiaoling,
Zhou Thomas J.,
Farrell John,
Chung Jaeyoon,
Naj Adam C.,
Lunetta Kathryn L.,
Farrer Lindsay AA.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1465
Subject(s) - minor allele frequency , genetics , biology , single nucleotide polymorphism , missense mutation , gene , allele , disease , allele frequency , bioinformatics , genotype , medicine , mutation
(measured by [F] Florbetapir PET) (p1⁄40.027) (Fig. 3). In addition, cis-eQTL mapping analysis revealed that rs10744645 is associated with FGF23 gene expression in the temporal cortex in healthy individuals (p1⁄40.013; BRAINEAC). Conclusions: This study shows that genetic variation in anti-aging gene FGF23 may be associated with less brain atrophy and better memory performance, and may promotes a resilient brain in AD.