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P1‐141: GENOME‐WIDE ANALYSES OF ISOLATED RELATIVE COGNITIVE IMPAIRMENTS IDENTIFIES SUGGESTIVE HITS IN FIVE STUDIES
Author(s) -
Wessels Madeline E.,
Crane Paul K.,
Mez Jesse,
Trittschuh Emily H.,
Saykin Andrew J.,
Fardo David W.,
Thornton Timothy A.,
Gibbons Laura E.,
Sanders Ruth Elizabeth,
Mukherjee Shubhabrata
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.144
Subject(s) - genome wide association study , cognition , genetic association , genetic architecture , psychology , population , demography , biology , genetics , single nucleotide polymorphism , quantitative trait locus , psychiatry , genotype , gene , sociology
with an excellent model fit (Figure 1). As hypothesized, the CRfactor significantly attenuated the effect of abnormal CSF-ADbiomarkers on cognitive decline (p1⁄40.02, Figure 2). Finally, a protective SNP in GAB2 was associated with CR using LASSO-regression. Importantly, GAB2 was unrelated to the latent factors of pathology. In contrast, APOE4 was associated with AD-pathology, but not with CR. Conclusions:ESEM offers a generic and versatile approach to derive a measure of CR incorporating multimodal pathology assessment and extensive cognitive test data. GAB2 might be a candidate gene for CR rather than AD pathology, but replications in larger samples with multimodal assessments (e.g. ADNI) are needed.