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P3‐074: HUMAN INDUCED NEURONS MODEL HALLMARKS OF ALZHEIMER'S DISEASE
Author(s) -
Schrank Sean,
Briggs Clark,
McDaid John,
Maigler Kathleen,
Marr Robert,
Stutzmann Grace E.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1430
Subject(s) - neuroscience , induced pluripotent stem cell , microglia , ryanodine receptor , disease , calcium in biology , neuroinflammation , biology , medicine , intracellular , microbiology and biotechnology , inflammation , immunology , embryonic stem cell , biochemistry , gene
compared with the baseline urine. Results: The urine AD7c-NTP levels from 19 participants at different time points behaved stably (P>0.05). Urine samples without any preservative increased over time, and compared with the NaHCO3 addition group, boric acid addition group behaved stably. Samples stored at 20 C and 70 C led to an obviously false positive. Conclusions: AD7c-NTP can be tested using random urine instead of the first morning urine. If the specimen cannot be tested in time, boric acid appears to be an acceptable preservative with storage at 4 C, freezing is not recommended.