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P3‐068: DEVELOPMENT OF AN ULTRA‐SENSITIVE DIGITAL IMMUNOASSAY (SIMOA) TO DETECT PSD‐95 IN CEREBROSPINAL FLUID AND BRAIN LYSATE
Author(s) -
Brock Mary,
Song Linan,
Zhao Mingwei,
Hanlon David,
Czerkowicz Julie,
Graham Danielle
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1424
Subject(s) - immunoassay , cerebrospinal fluid , detection limit , recombinant dna , chemistry , lysis , biomarker , chromatography , biology , biochemistry , gene , immunology , antibody , neuroscience
PSD-95 (postsynaptic density protein 95) is a membrane-associated guanylate kinase (MAGUK) scaffolding protein encoded by the DLG4 gene and is associated with excitatory synapses. This protein is an emerging biomarker in Alzheimer’s disease (AD) research as recent studies have correlated a decline of PSD-95 with neuronal loss, behavioral decline, and other measures of synaptic plasticity. [3, 4, 5]