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P3‐067: POLY(LACTIC ACID) (PLA) ELECTROSPUN FIBERS IMPROVE NEUROGENESIS AND REDUCE β‐AMYLOID PLAQUES IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE
Author(s) -
Salles Geisa Nogueira,
Calió Michele Longoni,
Holscher Christian,
Pacheco-Soares Cristina,
Porcionatto Marimelia,
Oliveira Lobo Anderson
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1423
Subject(s) - doublecortin , neurogenesis , lactic acid , chemistry , genetically modified mouse , dentate gyrus , electrospinning , hippocampus , biophysics , transgene , microbiology and biotechnology , biochemistry , medicine , biology , polymer , organic chemistry , genetics , bacteria , gene
global deterioration scale(GDS). Results: After adjusting for age, a significant difference in fibrinogen (P 1⁄4 0.045) and CRP (P 1⁄4 0.042) levels was observed among the three groups. Fibrinogen and CRP levels were higher in patients with AD than in subjects with MCI and healthy controls. Fibrinogen and CRP levels negatively and positively correlated with MMSE-K and GDS scores, respectively. Fibrinogen and CRP levels were also positively correlated. Conclusions: The present study suggests that fibrinogen and CRP levels of patients with AD might be higher than those of subjects with MCI and healthy controls. Fibrinogen and CRP levels might be negatively correlated with cognitive function. And we expect fibrinogen and CRP levels might have the role of inflammatory biomarkers for AD.