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P3‐065: THE BARNES MAZE TEST: A DRY LAND BEHAVIORAL TEST TO ANALYZE ALZHEIMER'S DISEASE MOUSE MODELS FOR SPATIAL LEARNING DEFICITS
Author(s) -
Rabl Roland,
Kurat Stephan,
Hernandez Iera,
Santiago-Mugica Estibaliz,
Flunkert Stefanie,
Hutter-Paier Birgit
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1421
Subject(s) - morris water navigation task , barnes maze , water maze , neuroscience , psychology , hippocampus , donepezil , hippocampal formation , spatial learning , dementia , medicine , disease , pathology
cerebral microbleed load was assessed using susceptibility weighted MRI at 9.4 T, The level of amyloid deposits and inflammation were assessed by immunostaining. Results: Noscapinetreatment augmented hypoperfusion in arcAb mice compared to control-treated arcAbmice in the cortex but not in the hippocampus and thalamus. The noscapine treatment also ameliorated the compromised vascular reactivity in the cortex but not hippocampus, caudate nucleus or thalamus of arcAbmice. The number of cerebral microbleeds did not differ between noscapine-treated and controltreated arcAb mice. Conclusions: Treatment with noscapine mitigated functional cerebrovascular deficits in arcAb mouse model. Thus, the kinin-kallikrein system constitutes a potential therapeutic target in AD.