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P3‐057: THERAPEUTIC EFFECTS OF A BRAIN PENETRATING BISPECIFIC ERYTHROPOIETIN‐TRANSFERRIN RECEPTOR ANTIBODY FUSION PROTEIN IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER'S DISEASE
Author(s) -
Chang Rudy,
Al Maghribi Abrar,
Vanderpoel Victoria,
Ing Austin,
Vasilevko Vitaly,
Cribbs David H.,
Boado Ruben,
Pardridge William M.,
Sumbria Rachita
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1413
Subject(s) - erythropoietin , transferrin receptor , neuroprotection , medicine , hippocampal formation , blood–brain barrier , fusion protein , pharmacology , microglia , endocrinology , hippocampus , immunology , receptor , central nervous system , biology , inflammation , biochemistry , gene , recombinant dna
Hydrophobic property of highest selective molecule; (B) Hydrophobic property of least selective molecule; (C) Electron withdrawing property of highest selective molecule; (D) Electron withdrawing property of least selective molecule. Blue cubes correspond to position where the substitution of a particular property group is favored and vice versa for the red cubes. Poster Presentations: Tuesday, July 24, 2018 P1086