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P3‐044: SUVN‐502, A PURE 5‐HT 6 RECEPTOR ANTAGONIST, ATTENUATES THE MEMORY DEFICIT CAUSED BY BILATERAL COMMON CAROTID ARTERY LIGATION
Author(s) -
Yathavakilla Sumanth,
Fernandes Joylee,
Muthyala Vishalakshi,
Goura Venkatesh,
Vincent Sthevaan,
Goyal Vinod Kumar,
Jayarajan Pradeep,
Nirogi Ramakrishna
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1399
Subject(s) - vascular dementia , dementia , cerebral blood flow , medicine , memory improvement , common carotid artery , receptor antagonist , morris water navigation task , antagonist , hippocampus , memory impairment , cognitive decline , anesthesia , psychology , neuroscience , receptor , cognition , disease , carotid arteries
after treatment. Student t-test was used to compare the different groups of animals. Animals were visually and histologically inspected for tumor formation. Results: Treatment of eSCs and mSCs by a less-invasive intravenous route in the MPTP PD rodent model provided augmentation in motor abilities at early (10 days post-treatment) and later (3 months post-treatment) time points. Also, this treatment was deemed to be safe from teratomas. Conclusions: Motor impairment observed in MPTP-induced PD mice ameliorates after the treatment with NPs, and this is more evident several days after the therapy. Therefore, peripheral administration of NPs could be a promising therapy to treat motor impairment associated to PD.