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P2‐596: ANTICHOLINERGIC MEDICATIONS, BENZODIAZEPINES, AND LONG‐TERM COGNITIVE DECLINE IN LARGE OBSERVATIONAL STUDIES: FINDINGS FROM THE ANTICHOLINERGICS, BENZODIAZEPINES, COGNITION AND DEMENTIA (ABCD) STUDY
Author(s) -
Richardson Kathryn,
Grossi Carlota,
Fox Chris,
Maidment Ian D.,
Loke Yoon,
Steel Nick,
Arthur Antony,
Myint Phyo,
Campbell Noll L.,
Brayne Carol,
Matthews Fiona,
Robinson Louise,
Savva George M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1291
Subject(s) - dementia , anticholinergic , observational study , cognitive decline , medicine , cognition , psychiatry , benzodiazepine , incidence (geometry) , pediatrics , disease , physics , receptor , optics
In the largest studies to date, our analyses suggest that benzodiazepines and anticholinergic medications affect cognition over the short-term. We observed no long-term dementia risk with benzodiazepine use, but small associations between certain anticholinergics (antidepressants, antiparkinsons, and urological drugs) and dementia that warrant further research. Systematic reviews – findings from other studies