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P2‐583: APOE4 ALLELE MODIFIES THE RISK‐PROTECTIVE FACTORS OF DEMENTIA: RESULTS FROM THE INVECE.AB LONGITUDINAL STUDY
Author(s) -
Guaita Antonio,
Vaccaro Roberta,
Poloni Tino Emanuele,
Zaccaria Daniele,
Abbondanza Simona,
Davin Annalisa,
Medici Valentina,
Ceretti Arcangelo,
Colombo Mauro,
Villani Simona
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1278
Subject(s) - dementia , medicine , comorbidity , longitudinal study , population , demography , incidence (geometry) , cumulative incidence , gerontology , disease , multivariate analysis , neuropsychology , epidemiology , cognition , psychiatry , environmental health , cohort , physics , pathology , sociology , optics
women. Methods: We analyzed data from 2009 through 2014 from the National Health Insurance System (NHIS) of Korea. A total of 4,485,775 women 40 to 84 years of agewho participated in both national health screening and breast cancer screening examination were included in this study. Medical information assessing hormone therapy status and any gynecologic and obstetric history was determined by self-reported questionnaires. In this study, we performed a cross-sectional analysis and usedmultivariable logistic regression analysis models. Results: Our analysis showed that HRT users had amaximal 19% lower risk of dementia in postmenopausal women when compared with non-HRT users. Significantly lower ORs (95% CI) were observed in individuals who had HRT 2 to 5 years (OR, 0.818; 95% CI, 0.7896-0.851), followed by those who had less than 2 years (OR, 0.861; 95% CI, 0.839-0.884) and then by those who had more than 5 years of treatment (OR 0.881; 95% CI, 0.786-0.851) after adjusting for age, parity, breast feeding, oral contraception, smoking status, alcohol intake, exercise habits, BMI, diabetes mellitus, hypertension, and lipid levels. These Ushaped patterns were similarly demonstrated in subgroup analysis for both Alzheimer’s disease(AD) and vascular dementia(VD) subjects. Conclusions: We found that the use of postmenopausal HRT for less than 5 years greatly reduced the risk of dementia in the general population of Korean women.