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P2‐500: PHYSICAL PERFORMANCE IN RELATION TO COGNITIVE FUNCTIONING IN PATIENTS WITH DISORDERS ALONG THE HEART‐BRAIN AXIS
Author(s) -
Hooghiemstra Astrid M.,
Leeuwis Anna E.,
Franken Leonie,
Brunner-La Rocca Hans-Peter H.P.,
Kappelle Jaap,
Oostenbrugge Robert J.,
Rossum Albert,
Biessels Geert Jan,
Flier Wiesje M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1193
Subject(s) - stroop effect , memory span , cognition , psychomotor learning , effects of sleep deprivation on cognitive performance , balance (ability) , audiology , psychology , cognitive test , medicine , cardiology , working memory , physical therapy , psychiatry
At baseline, conscientiousness and neuroticism were correlated with CSF tau and ptau suggesting that personality tracks disease progression. Importantly, panel analyses indicate that changes in biomarkers occur first which lead to changes in self-assessed personality. Thus, accumulation of AD biomarkers induces changes in personality as opposed to personality traits predisposing an individual to developing pathology in DIAN.