P2‐489: CHARACTERIZING COGNITIVE AND NEURAL ALTERATIONS AMONG HEALTHY PARTICIPANTS WITH A GENETIC PREDISPOSITION FOR ALZHEIMER'S DISEASE

analysis revealed that the mean of Aptest scores for subjects scoring in healthy ranges on subsequent cognitive measures was 28 (median 1⁄4 29), and the mean of Aptest scores for subjects scoring in the range of mild cognitive impairment on subsequent measures was 18 (median 1⁄418). In contrast, the mean of MMSE scores for subjects scoring in healthy ranges on subsequent cognitive measures was 28 (median1⁄428), and the mean of MMSE scores for subjects scoring in the range of mild cognitive impairment on subsequent measures was 25.8 (median 1⁄4 26). Conclusions:Based comparative analysis with cognitive measures, Aptest appears to be sensitive to early stages of cognitive decline/MCI in older adults. Early comparisons indicate that Aptest may be more sensitive to early stages of MCI than the MMSE. In addition, Aptest appears to be more predictive of subsequent blinded administrations of cognitive tests than the MMSE. Further analysis is warranted and ongoing data collection is scheduled to continue throughout 2018.