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P2‐475: NEUROPATHOLOGIC CORRELATES OF ENLARGED PERIVASCULAR SPACES IN A COMMUNITY COHORT OF OLDER ADULTS
Author(s) -
Petit Carles Javierre,
Schneider Julie A.,
Makkinejad Nazanin,
Tamhane Ashish A.,
Bennett David A.,
Arfanakis Konstantinos
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1168
Subject(s) - perivascular space , cohort , neuropathology , ex vivo , autopsy , cohort study , medicine , pathology , alzheimer's disease , psychology , gerontology , disease , in vivo , biology , microbiology and biotechnology
Background:Enlarged perivascular spaces (EPVS), also known as Virchow-Robin spaces, are cerebrospinal fluid-filled spaces surrounding blood vessels. EPVS have been associated with aging, small-vessel disease and cognitive decline. However, the relationship of EPVS with age-related neuropathologies has not been thoroughly investigated, and published studies suffer from small sample-size, lack of thorough neuropathological assessment, and/or long intervals between in-vivo imaging and autopsy. Therefore, the purpose of this research was to assess the neuropathologic correlates of EPVS burden using a study design that addresses the above shortcomings by combining ex-vivo MRI and pathology on a large community cohort of older adults. Methods: Cerebral hemispheres were obtained from 281 deceased participants of the Rush Memory and Aging Project and the Religious Orders Study, two longitudinal, epidemiologic clinical-pathologic cohort studies of aging. All hemispheres were imaged ex-vivo on a 3T clinical MRI scanner, while immersed in 4% formaldehyde solution, using a 2D fast spin-echo sequence with multiple echo-times (TEs). Following ex-vivo MRI, hemispheres underwent neuropathologic examination. Demographic, clinical and neuropathologic information is included in Figure 1. EPVS burden was manually assessed using a four-level scale. Examples are shown in Figures 2-5. Intra-