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P2‐470: DIFFERENT CO‐LOCALIZATION OF NEUROINFLAMMATORY MARKERS IN PLAQUES OF ATYPICAL COMPARED TO TYPICAL ALZHEIMER'S DISEASE
Author(s) -
Boon Baayla D.C.,
Hoozemans Jeroen J.M.,
Scheltens Philip,
Rozemuller Annemieke M.,
Bouwman Femke H.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1163
Subject(s) - pathology , microglia , cd68 , neuroinflammation , senile plaques , amyloid (mycology) , alzheimer's disease , immunohistochemistry , medicine , biology , disease , immunology , inflammation
done when the participant died. Results:We recruited 97 participants, 63 from clinic, and 34 from community. Among them 11 died and autopsied. The clinical diagnosis of the patients who got autopsy were four Alzheimer disease related cognitive impairment, two vascular disease related cognitive impairment, two non-fluent variant primary progressive aphasia, one leukoencephalopathy, one fronto-temporal dementia, and one Creutzfeldt–Jakob disease. There were five patients who underwent amyloid PET in their lives: two Alzheimer’s disease, one mixed Alzheimer’s disease and vascular dementia, one fronto temporal dementia and, and one Creutzfeldt–Jakob disease cases. Conclusions: Clinical and neuropathologic information to be obtained from this cohort in the future will provide a deeper understanding of the neuropathologic mechanisms of cognitive impairment in Asia, especially Korea.