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P2‐469: THE BRAIN DONATION PROGRAM IN SOUTH KOREA
Author(s) -
Kim Yeshin,
Suh Yeon-Lim,
Kim Seung Joo,
Bae Moon Hwan,
Kim Jae Bum,
Kim Yuna,
Choi Kyung-Chan,
Huh Gi Yeong,
Kim Eun-Joo,
Kang Hyun Wook,
Lee Jung Seok,
Kim Byeong-Chae,
Lee Kyung-Hwa,
Lee Min-Cheol,
Lee Ho-Won,
Lim Tae Sung,
Seeley William W.,
Kim Hee Jin,
Na Duk L.,
Lee Kyung Hoon,
Seo Sang Won
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1162
Subject(s) - neuropathology , dementia , autopsy , medicine , disease , neuropsychology , vascular dementia , pathological , clinical dementia rating , pathology , pediatrics , psychiatry , cognition
pathology, several amyloid plaques were found within the neocortex (fig.2), basal ganglia and entorhinal cortex (Thal stage 3, Montine A2). Diffuse tau pathology was present at the entorhinal cortex (fig.3), and to a lesser degree, at the temporal and parietal cortices (Braak stage II, Montine B2 and C3). a-synuclein immunoreactivity was detected in Substantia Nigra (fig.4) and amygdala (Beach stage III). Conclusions:Our data confirm that neuropathological lesions are part of “normal” aging. They often do not cause a disease when a compensation is triggered. In this subject, the preservation of cognitive abilities may be correlated to his cognitively and socially active life, preventing the clinical manifestation of the disease.