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P2‐465: THE ROLE OF COMPREHENSIVE INVESTIGATION IN THE DIAGNOSTIC WORK‐UP OF YOUNGER PATIENTS WITH COGNITIVE IMPAIRMENT
Author(s) -
Lim Levinia,
Yong Ting Ting,
Wong Benjamin,
Lyn Ng Adeline Su,
Ting Simon,
Hameed Shahul,
Ng Kok Pin,
Kandiah Nagaendran
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1158
Subject(s) - dementia , medical diagnosis , neuropsychology , medicine , frontotemporal dementia , vascular dementia , neuropsychological assessment , magnetic resonance imaging , pediatrics , cognitive decline , psychology , cognitive impairment , disease , psychiatry , cognition , pathology , radiology
and adjusted for age. WM tracks that significantly correlated with EYO were further evaluated with pathological biomarkers (cerebrospinal fluid (CSF) amyloid and tau). Results:Significant changes in mean diffusivity and radial diffusivity were seen within parietal and frontal regions for MC CDR>0 compared to other groups (Fig1). Within the MC group, three WM tracks were significantly associated with EYO: forceps major (FMaj), cingulum, and posterior corpus callosum (PCC). Initial decline in WM for MC and NC occur around 10 years prior to EYO. A significant interaction was observed for mutation status and EYO in the cingulum. CSF amyloid correlated with average mean fractional anisotropy (FA; p1⁄40.02) but not with any specific WM track. CSF T-tau correlated with FA for the PCC (p1⁄40.04) and FMaj (p1⁄40.001). Conclusions: This data reveals that WM integrity in ADAD is most strongly affected in posterior/parietal white matter with more advanced disease. These changes suggest that structural decline may initiate just before EYO that associates with the underlying pathology.