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P2‐457: THE ASSOCIATION BETWEEN HIPPOCAMPAL SUBFIELD VOLUMES AND EDUCATION IN COGNITIVELY NORMAL OLDER ADULTS AND AMNESTIC MILD COGNITIVE IMPAIRMENT PATIENTS
Author(s) -
Kang Dong Woo,
Lee Chang Uk,
Lim Hyun Kook
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1150
Subject(s) - subiculum , hippocampal formation , neuropsychology , psychology , association (psychology) , cognition , neuroscience , medicine , audiology , dentate gyrus , psychotherapist
predicted steeper fluency decline among APOE-ε4 carriers only (pvalues<0.01). Lower baseline left frontal, left temporal, and right temporal lobe CVR predicted steeper memory decline (p-values<0.04). An interaction revealed that among APOE-ε4 carriers, higher left temporal lobe CVR predicted steeper decline in delayed recall (p1⁄40.04). Conclusions: Lower CBF and CVR predicted steeper memory decline. However, higher CBF and CVR among APOE-ε4 carriers may reflect hemodynamic compensatory responses to early neurodegenerative changes, predicting worse cognitive prognosis. Consistent with prior research, semantic fluency emerged as a particularly robust early cognitive marker of decline, but its associations appeared limited to APOE-ε4 carriers. Pathological hyperperfusion in the frontal and parietal cortices may underlie semantic fluency impairment among individuals at risk for AD. Funding: IIRG-08-88733, R01-AG034962, R01-AG056534, R01-NS100980, K24-AG046373, F32AG058395,T32-MH064913, R25-GM062459, UL1-TR000445, S10-OD023680.