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P2‐455: STRUCTURAL INTEGRITY IN SUBJECTIVE COGNITIVE DECLINE, MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE BASED ON MULTICENTER DIFFUSION TENSOR IMAGING: RESULTS FROM THE DELCODE STUDY
Author(s) -
Brueggen Katharina,
Dyrba Martin,
Cardenas-Blanco Arturo,
Nestor Peter,
Schneider Anja,
Buerger Katharina,
Peters Oliver,
Priller Josef,
Wiltfang Jens,
Laske Christoph,
Wagner Michael,
Spottke Annika,
Düzel Emrah,
Jessen Frank,
Teipel Stefan J.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1148
Subject(s) - splenium , diffusion mri , corpus callosum , fractional anisotropy , cingulum (brain) , white matter , cognitive decline , internal capsule , psychology , alzheimer's disease neuroimaging initiative , corona radiata (embryology) , medicine , alzheimer's disease , cardiology , pathology , audiology , disease , magnetic resonance imaging , dementia , radiology , ovarian follicle , hormone , cumulus oophorus
discrimination between NC and AD stratified by age was also calculated, optimal MTA cut-off values for the age ranges 50-64, 65–74, 75-84 were 1.0, 1.5, 2.0, the sensitivity and specificity were 92.3% and 68.4%; 90.4% and 85.2%, 70.8% and 82.3%, respectively(Table 1). Conclusions: This new age-based cutoff of MTA scale showed better diagnostic accuracy for detecting AD with high sensitivity and specificity in Chinese population.