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P2‐429: PRESERVED CORTICAL THICKNESS IN ALZHEIMER SIGNATURE REGIONS: RESISTANCE TO AMYLOID ACCUMULATION IN NORMAL AGING
Author(s) -
Veilleux Catherine,
Joubert Sven,
Bernier Michaël,
Sévigny-Dupont Pénélope,
Lavallée Marie-Maxime,
Joannette Maude,
Nikelski Jim,
Chertkow Howard,
Kevin Whittingstall,
Bocti Christian
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1121
Subject(s) - precuneus , parahippocampal gyrus , posterior cingulate , angular gyrus , superior frontal gyrus , supramarginal gyrus , superior temporal gyrus , middle frontal gyrus , pittsburgh compound b , neuroscience , inferior parietal lobule , psychology , cognitive reserve , cognitive decline , temporal cortex , cortex (anatomy) , episodic memory , temporal lobe , medicine , cognition , dementia , cognitive impairment , disease , functional magnetic resonance imaging , epilepsy
PET images of healthy control subjects. The resulting total volume of hypometabolic voxels at uncorrected p 0.001was dichotomized using the cutoff of 31.0 ml derived by ROC analysis and the Youden criterion (quantPET). VisPETand quantPETwere tested for prediction of cognitive decline according to the change of CDR-SB. Results: Average time between FDG PET and clinical follow-up was 15.463.1 months. Sensitivity, specificity, accuracy, PPV and NPV for prediction of cognitive decline were (visPET/quantPET): 67.4/83.7%, 64.7/64.7%, 66.7/78.8%, 84.6/87.2%, 40.7/57.9%, respectively. Conclusions: Brain FDG PET provides a high PPV for prediction of further cognitive decline of acutely hospitalized geriatric patients with newlymanifested, clinically uncertain cognitive impairment, particularly when using the total volume of hypometabolism for prediction. Its NPV is limited.