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P2‐419: PROJECTION TO LATENT SPACES DISENTANGLES SPECIFIC CEREBRAL MORPHOMETRIC PATTERNS ASSOCIATED WITH AGING AND PRECLINICAL AD
Author(s) -
Casamitjana Adriá,
Petrone Paula Marcela,
Artigues Miquel,
Molinuevo José Luis,
Gispert Juan Domingo,
Vilaplana Verónica
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1111
Subject(s) - latent variable , brain size , correlation , confounding , neuroimaging , covariance , magnetic resonance imaging , grey matter , mathematics , psychology , white matter , statistics , medicine , neuroscience , radiology , geometry
the presence of ApoE4 positive status were adjusted for the comparison. Results: Compared with non-diabetes group, executive function(Trail Making Test B) is significant impaired in both the diabetes group and pre-diabetes group. Delayed memory(Rey Auditory Verbal Learning Test) is significantly impaired in the diabetes group. There was significant difference between the three groups in the total left hippocampal volume(F1⁄43.257, P1⁄40.046) and the left hippocampal tail volume(F1⁄44.623, P1⁄40.014).There was a significant correlation between the A1c and the volume of the left hippocampal tail(R1⁄4-0.334, P1⁄40.009), bilateral subiculum(RL1⁄4-0.291, P1⁄40.024; RR1⁄4-0.271, P1⁄40.036) and bilateral molecular layer(RL1⁄4-0.307, P1⁄40.017; RR1⁄4-0.283, P1⁄40.028) after adjusting for covariants. Conclusions: These results support the view that for diabetes, the left posterior hippocampus, especially the hippocampal tail, may be an earlier affected region and then the atrophy process gradually spread to other hippocampal subfileds, causing the executive function loss. More clinical attention should be paid in adults with pre-diabetes status for the earlier cognitive impairment prevention.