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P2‐409: PERIPHERAL INFLAMMATION AND BRAIN GLUCOSE METABOLISM IN NONDEMENTED OLDER ADULTS
Author(s) -
Braskie Meredith N.,
Thompson Paul M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1101
Subject(s) - posterior cingulate , medicine , neuroimaging , temporal lobe , neuropathology , positron emission tomography , cerebrospinal fluid , inflammation , temporal cortex , alzheimer's disease , systemic inflammation , psychology , cortex (anatomy) , endocrinology , pathology , neuroscience , disease , epilepsy
was available (56.3%). Results:MTA score (mean6SD: 0.660.7 for both sides) had a skewed distribution, half of the sample scoring 0 (on the right: n1⁄4480, 51.3%; on the left: n1⁄4475, 50.7%), and less than 10% scoring more than 1 (on the right: n1⁄471, 7.6%; on the left: n1⁄465, 6.9%). No significant difference was observed between sides in MTA scores (p1⁄41.000). The 90 percentile cut-off of the age-specific distribution increased from 1 (at age 20-59) to 2 (at age 60-79) and then up to 4 for subjects over 80s (Figure). No significant difference was observed between APOε4 carriers and non-carriers, neither in the whole sample (p1⁄40.23 right; p1⁄40.88 left), nor in the subsets over 60 (p1⁄40.96 right; p1⁄40.72 left). Conclusions: This study provides the first normative values for MTA in the general population. According to the literature, our data suggest the presence of different age-related cut-offs and, thus, the need to consider different thresholds depending on age. References: 1. Scheltens P et al. Atrophy of medial temporal lobes on MRI in "probable" Alzheimer’s disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992; 55(10):967-972. 2. Galluzzi S et al. The Italian Brain Normative Archive of structural MR scans: norms for medial temporal atrophy and white matter lesions. Aging Clin Exp Res. 2009; 21(4-5):266-276.