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P2‐390: DIFFERENTIAL HIPPOCAMPAL SUBFIELD LOSS IN DIFFERENT PHENOTYPES OF YOUNG ONSET ALZHEIMER'S DISEASE
Author(s) -
Parker Thomas D.,
Slattery Catherine F.,
Nicholas Jennifer M.,
Paterson Ross W.,
Foulkes Alexander JM.,
Malone Ian B.,
Thomas David L.,
Modat Marc,
Cash David M.,
Crutch Sebastian J.,
Yong Keir,
Ourselin Sebastien,
Fox Nick C.,
Schott Jonathan M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1081
Subject(s) - subiculum , hippocampal formation , dentate gyrus , entorhinal cortex , hippocampus , neuroscience , hippocampal sclerosis , atrophy , temporal lobe , medicine , pathology , psychology , epilepsy
to controls. Connections were predominantly impaired in frontal and occipital junctions. There was a graduation from controls to MCI and from MCI to AD. CSF markers differed not between AD and MCI. For all subjects a low correlation was observed for MMSE and CSF tau and a number of connections including fronto-parietal and fronto-occipital. Conclusions: In this investigation with an rs-fNIRS it was demonstrated a good feasibility of the method. Moreover it turned out to be sufficient to detect substantial differences between controls andMCI subjects, and AD patients, respectively. For further longitudinal studies it may be worth to explore whether rs-fNIRS has the capability to predict thoseMCI subjects that convert into AD.