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P2‐383: CONVERGENCE ANALYSIS OF MICRO‐LESIONS (CAML) FOR DIFFUSE PATHOLOGIES
Author(s) -
Rosen Allyson C.,
Soman Salil,
Bhat Jyoti,
Laird Angela R.,
Stephens Jeffrey,
Eickhoff Simon B.,
Fox P. Mickle,
Long Becky Yanyu,
Dinishak David,
Ortega Mario,
Lane Barton,
Wintermark Max,
Hitchner Elizabeth,
Zhou Wei
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1074
Subject(s) - medicine , diffusion mri , magnetic resonance imaging , effective diffusion coefficient , radiology , carotid arteries , nuclear medicine , surgery
NAWM. For each subject, the periventricular WMH (red circles), deep WMH (green triangles), and NAWM (blue squares) are displayed on a ternary plot (created using ggtern package in R), with the location corresponding to the relative WM-GM-CSF fraction of the lesions (or normal WM). The relative tissue fraction is shown as a percentage along the left (WM-like), right (GM-like), and bottom (CSF-like) axes. Remarkably, the periventricular WMH, deep WMH, and NAWM appear in distinct clusters, exhibiting their different profiles with regard to relative tissue fractions obtained from SS3T-CSD diffusion data. able 1 ata presented as mean (SD) or number of males (%) for sex. Reported -values from student’s t-tests for age and intracranial volume (ICV), chiquare test for independence for sex, and one-way ANCOVA controlling for V for PVWMH (periventricular WMH), DWMH (deep WMH) and total MH volumes. No significant differences were observed between groups r age, gender, ICV, or DWMHvolume. PVWMHvolumewas significantly reater in AD compared to controls (as was total WMH volume, as xpected) HC (n 1⁄4 94) AD (n1⁄448) Test statistic p-value ge (years) 78.4 (7.4) 77.4 (8.3) t (140) 1⁄4 0.73 0.47 ex (male) 44 (46.8) 21 (43.8) X (1, n1⁄4142) 1⁄4 0.03 0.87