P2‐383: CONVERGENCE ANALYSIS OF MICRO‐LESIONS (CAML) FOR DIFFUSE PATHOLOGIES

NAWM. For each subject, the periventricular WMH (red circles), deep WMH (green triangles), and NAWM (blue squares) are displayed on a ternary plot (created using ggtern package in R), with the location corresponding to the relative WM-GM-CSF fraction of the lesions (or normal WM). The relative tissue fraction is shown as a percentage along the left (WM-like), right (GM-like), and bottom (CSF-like) axes. Remarkably, the periventricular WMH, deep WMH, and NAWM appear in distinct clusters, exhibiting their different profiles with regard to relative tissue fractions obtained from SS3T-CSD diffusion data. able 1 ata presented as mean (SD) or number of males (%) for sex. Reported -values from student’s t-tests for age and intracranial volume (ICV), chiquare test for independence for sex, and one-way ANCOVA controlling for V for PVWMH (periventricular WMH), DWMH (deep WMH) and total MH volumes. No significant differences were observed between groups r age, gender, ICV, or DWMHvolume. PVWMHvolumewas significantly reater in AD compared to controls (as was total WMH volume, as xpected) HC (n 1⁄4 94) AD (n1⁄448) Test statistic p-value ge (years) 78.4 (7.4) 77.4 (8.3) t (140) 1⁄4 0.73 0.47 ex (male) 44 (46.8) 21 (43.8) X (1, n1⁄4142) 1⁄4 0.03 0.87