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P2‐379: POTENTIAL APPLICATION OF 18F‐THK5351 AND ITS DERIVATIVES FOR IMAGING ASTROGLIOSIS IN HUMAN BRAIN
Author(s) -
Okamura Nobuyuki,
Harada Ryuichi,
Ishiki Aiko,
Furumoto Shozo,
Arai Hiroyuki,
Yanai Kazuhiko,
Kudo Yukitsuka
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1070
Subject(s) - astrogliosis , monoamine oxidase b , recombinant dna , in vitro , human brain , pharmacology , chemistry , monoamine oxidase , biochemistry , medicine , biology , enzyme , neuroscience , central nervous system , gene
Individuals with MCI have shown worse performance on the CDT relative to age-matched controls, but to date, there has been limited examination of the neural basis for CDT and how it is affected by MCI. This is the first study to use functional magnetic resonance imaging (fMRI), combined with a novel MRI-compatible tablet and real-time visual feedback, to reveal brain regions activated during the CDT in both healthy and MCI groups. Results may help identify changes in brain function associated with impaired CDT performance in MCI. Methods: This study combined fMRI, an MRI-compatible tablet with stylus and an augmented reality system with visual hand feedback, to measure brain activity of 11 patients with MCI and 11 age-matched control participants during performance of the CDT. The CDTwas scored using the Rouleau method. Statistical activation maps were calculated using a general linear model (thresholded at an adjusted False Discovery Rate of q1⁄40.05). Results: Both patients with MCI and healthy controls showed consistent activation in the bilateral occipital lobes, parietal lobes, supplementary motor area and right temporal lobe during the CDT (Figure 1). Patients withMCI exhibited reduced negative activation in the left temporal lobe and increased positive activation in the frontal lobes. Although individuals with MCI scored lower on the CDT and had a longer time of completion of the task compared to healthy control participants, the results of a Wilcoxon test were not statistically significant (p > 0.102) (Figure 2 & 3). Conclusions: This is the first study to show patterns of brain activation in MCI and healthy control groups during performance of the CDT. The altered temporal activation among patients with MCI may reflect underlying neuropathological changes. In contrast, the observed increased frontal activity may play a compensatory role in maintaining task performance, which may explain why performance was not significantly different between the two groups. Functional connectivity can demonstrate the effects of MCI on task performance, even when behavioural results appear unimpaired.