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P2‐367: ANTI‐CORRELATED NETWORKS SHOW PARADOXICAL INCREASED CORTICAL THICKNESS IN ALZHEIMER'S DISEASE
Author(s) -
Darby Ryan,
Dickerson Brad C.,
Fox Michael
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1058
Subject(s) - atrophy , neuroscience , neuropathology , cortex (anatomy) , diaschisis , connectome , disease , cerebral cortex , visual cortex , neuroimaging , psychology , medicine , pathology , cerebellum , functional connectivity
controls following thresholding of automated search results for parameters with a posterior probability of 95% of being non-zero. Connections for controls are depicted in Figure 2. Patients showed decreased self-inhibition, denoted by a positive value , in the posterior cingulate cortex (PCC), left and right hippocampal formation (LHF, RHF), and left and right lateral parietal cortex (LLPC, RLPC) compared to controls. Additionally, decreased connectivity was noted from LLPC to the medial prefrontal cortex and increased connectivity was noted from RLPC to PCC. Conclusions:Effective connectivity differed between AD/MCI and control within the DMN. Decreased self-inhibition would increase time to return to baseline, potentially influencing behavioral outcomes.