Premium
P2‐354: POSTERIOR COMMUNICATING ARTERY VARIATION IN THE CIRCLE OF WILLIS IS ASSOCIATED WITH COMPROMISED TEMPORAL LOBE HEMODYNAMICS IN OLDER ADULTS
Author(s) -
Cambronero Francis E.,
Liu Dandan,
Bown Corey,
Pechman Kimberly R.,
Khan Omair,
Kresge Hailey A.,
Herbener Samantha,
Wang Hanyang,
Bogner Jaclyn,
Thompson Jennifer,
Lambros Sarah,
Walljasper Lily,
Davis L. Taylor,
Gifford Katherine A.,
Hohman Timothy J.,
Donahue Manus J.,
Jefferson Angela L.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1045
Subject(s) - circle of willis , posterior cerebral artery , medicine , anterior communicating artery , posterior communicating artery , anterior cerebral artery , temporal lobe , hemodynamics , cerebral arteries , cardiology , magnetic resonance angiography , stroke (engine) , magnetic resonance imaging , psychology , middle cerebral artery , radiology , ischemia , subarachnoid hemorrhage , internal carotid artery , epilepsy , mechanical engineering , engineering , psychiatry
which mean diffusivity(MD), fractional anisotropy(FA) and white matter hyperintensity(WMH) were calculated. Cerebrospinal fluid was obtained for 63 subjects and Ab, tau and phosphorylated-tau levels were measured. Subjects were classified as low-binders when rs6971 homozygous and high-binders when rs6971 homozygous. Chi-square and t-tests were used for demographic description whereas linear models adjusted for covariates were used to assess the effect of rs6971 on the available phenotypes. Results: The rs6971 minor-allele frequency in our study population is 0.30 (48,8% CC,41.7% CT,9.4% TT) (Figure 1), which is in accordancewith frequencies described for Caucasian populations in public databases. Differences in gender, diagnosis and APOE-e4 status were not observed across rs6971 genotypes. The rs6971 was not associated with any cognitive score as well as with none of the CSF or imaging biomarkers tested here. Conclusions:The study population under investigation is genetically representative of the Caucasian population –for the rs6971–and the SNP showed no effect in any dementia-related phenotypes analyzed here. Results confirm that the cohort is appropriate for neuroimaging studies linking dementia and neuroinflammation.