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P2‐349: DIFFERENT COMBINATIONS OF DIAGNOSTIC TESTS DISCRIMINATE SPECIFIC SUBTYPES OF DEMENTIA
Author(s) -
Rhodius- Meester Hanneke FM.,
Bruun Marie,
Baroni Marta,
Gjerum Le,
Remes Anne,
Urhemaa Timo,
Tolonen Antti,
Rueckert Daniel,
Gils Mark,
Lemstra Evelien,
Barkhof Frederik,
Frederiksen Kristian Steen,
Waldemar Gunhild,
Scheltens Philip,
Soininen Hilkka,
Mecocci Patrizia,
Koikkalainen Juha,
Lotjonen Jyrki,
Hasselbalch Sten Gregers,
Flier Wiesje M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1039
Subject(s) - dementia , vascular dementia , frontotemporal dementia , diagnostic accuracy , dementia with lewy bodies , medical diagnosis , lewy body , medicine , cognitive test , disease , pathology , cognition , psychology , psychiatry
TDP-43), ii) covarying with CSF biomarkers (Ab42, total tau, ptau) and iii) covarying with episodic memory scores (FCSRT, Landscape Test and CERAD Constructional Praxis recall). Results:Amyloid/Tau pathology affected mainly posterior HC while anterior left HC was more atrophied in TDP-43pathies. We also observed a significant correlation between posterior hippocampal atrophy and AD CSF biomarkers levels. In addition, visual memory scores correlated with posterior HC atrophy, whereas verbal memory correlated with both anterior and posterior hippocampal atrophy. Conclusions:These findings fit well with the hypothesis that HC is involved in two different cortical systems that harbor different cognitive functions, which could have distinct vulnerability to different proteinopathies. Taken together, these data suggest that there is a potential differentiation along the hippocampal longitudinal axis based on the underlying pathology, which could be used as a potential biomarker to identify the underlying pathology in different neurodegenerative diseases.