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P2‐330: RARE V180I MUTATION IN PRNP GENE OF A KOREAN PATIENT WITH ALZHEIMER'S DISEASE
Author(s) -
Pyun Jung Min,
Kang Min Ju,
Park Young Ho,
Kim SangYun
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1020
Subject(s) - prnp , atrophy , medicine , pathology , dementia , memory impairment , point mutation , temporal lobe , cerebral atrophy , mutation , disease , epilepsy , cognition , biology , genetics , gene , psychiatry , prion protein
showed faster decline in OIthan OI+ patients (b1⁄44.60, p<0.001, CI [2.77; 6.48]) before and after adjusting for age. Logistical and c testing suggested a trend between OI and more than 2 points MoCA decline (p 1⁄4 0.08), with a sensitivity of 0.85 and specificity of 0.44. Conclusions: Accurately identifying the smell of ground coffee correlates with MoCA scores and likely distinguishes non-neurodegenerative NCDs from AD. OIpatients tend to decline at a faster rate than OI+ patients. We demonstrate a possible trend towards efficacy of NSOITs as a screening tool for cognitive decline.