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P2‐321: ALZHEIMER'S DISEASE: TYPE 2 DIABETES MELLITUS IS ASSOCIATED WITH LOWER MINI‐MENTAL STATE EXAM SCORES WHEN COMPARED TO PRE‐DIABETIC PATIENTS
Author(s) -
Komatsu Caroline,
Komatsu Ricardo S.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1011
Subject(s) - dementia , diabetes mellitus , medicine , type 2 diabetes mellitus , disease , risk factor , type 2 diabetes , alzheimer's disease , insulin resistance , endocrinology
Background:Epidemiological studies provide convincing evidences for a significant association between type 2 Diabetes Mellitus (T2DM) and mild cognitive impairment or dementia, and furthermore suggest that the T2DM is a significant risk factor for the development of Alzheimer’s disease (AD). The studies on postmortem human brain tissue provide solid evidences that the AD is associated with fundamental abnormalities in the mechanisms of insulin/IGF signaling, which are highly correlated with the development and the progression of structural, molecular and biochemical lesions, correlated with dementia. In spite of the abnormalities noted in the AD share common characteristics with the T2DM, they are, nevertheless, distinct by the dual presence of trophic factor deficiencies and trophic factor’s receptor resistance, which accurately reflects the fact that the AD engages selectively the brain and has molecular and biochemical characteristics that overlap with T2DM. This study aims to verify the correlation between the blood glucose levels and the mini-mental state examination (MMSE) scores in outpatients with the diagnostic of Alzheimer’s disease (AD) and pre – diabetes/T2DM. Methods: 56 outpatients with the diagnostic of Alzheimer’s disease (AD) according to criteria proposed by NINCDS-ADRDA (2011) and pre – diabetes/T2DM, followed up in a Geriatrics Clinic, had their glucose serum levels assessed andMMSE scores evaluated. Results: 35 patients presented pre – diabetes levels of blood glucose (62,5%) and 21 patients presented diabetes levels of blood glucose (37,5%). From the pre-diabetes group 3 patients (8,58%) presented severe cognitive impairment (MMSE < 10), 20 patients (57,14%) presented moderate cognitive impairment (MMSE 1⁄4 10 – 20) and 12 patients (34,28%) presented mild cognitive impairment (MMSE > 20). From the diabetes group 4 patients (19,05%) presented severe cognitive impairment, 13 patients (61,90%) presented moderate cognitive impairment and 4 patients (19,05%) presented mild cognitive impairment. Both groups, pre-diabetes and T2DM, presented on average the same educational level: 8,17 and 8,43 years respectively. Conclusions: In this sample of patients with AD, T2DM is associated with lower MMSE scores when compared with pre-diabetic patients.